Local Transplantation of G-CSF-Mobilized CD34+ Cells in a Patient With Tibial Nonunion: A Case Report
Abstract:Although implantation of crude bone marrow cells has been applied in a small number of patients for fracture healing, transplantation of peripheral blood CD34+ cells, the hematopoietic/endothelial progenitor cell-enriched population, in patients with fracture has never been reported. Here, we report the first case of tibial nonunion receiving autologous, granulocyte colony stimulating factor mobilized CD34+ cells accompanied with autologous bone grafting. No serious adverse event occurred, and the novel therapy performed 9 months after the primary operation resulted in bone union 3 months later without any symptoms including pain and gait disturbance.
Document Type: Research Article
Affiliations: Department of Orthopedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
Publication date: September 1, 2011
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