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Open Access Study on the Preservation With CO (PCO = 200‐2,000 hPa), Resuscitation, and Heterotopic Transplantation of an Isolated Rat Heart

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Abstract:

In this experiment, CO was used as a gas mixture in a reversible relationship with O2. CO was added in a gas form mixed with O2. An isolated donor rat heart was obtained, exposed to a gas mixture such as PO2 = 1,800 hPa and PCO = 200 hPa, and PO2 = 1,000 hPa and PCO = 1,000 hPa in a 2 ATA high-pressure chamber and preserved in a refrigerator at 4°C. This report demonstrates that significant reproducibility has been verified. The heart was removed from the refrigerator 24 h later and heterotopic heart transplantation was performed in the right neck of a recipient rat and the pulsating of the transplanted heart was detected by an electrocardiogram.

Keywords: Desiccation; Heterotrophic transplantation; Isolated rat heart; Perfluorocarbon (PFC); Preservation; Resuscitation

Document Type: Research Article

Affiliations: 1: Kanagawa University Faculty of Science, Hiratsukashi, 259-1293 Japan. yoshiy412@hotmail.co.jp 2: Kanagawa University Faculty of Science, Hiratsukashi, 259-1293 Japan 3: Kanagawa University Faculty of Science, Hiratsukashi, 259-1293 Japan

Publication date: 2009-05-01

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  • Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.
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