@article {Cho:2009:0963-6897:1359,
	author = "Cho, Sung-Rae and Kim, Yong Rae and Kang, Hoi-Sung and Yim, Sun Hee and Park, Chang-il and Min, Yoo Hong and Lee, Bae Hwan and Shin, Ji Cheol and Lim, Jong-Baeck",
	title = "Functional Recovery After the Transplantation of Neurally Differentiated Mesenchymal Stem Cells Derived From Bone Barrow in a Rat Model of Spinal Cord Injury",
	journal = "Cell Transplantation",
	volume = "18",
	number = "12",
	year = "2009",
	abstract = "This study was designed to investigate functional recovery after the transplantation of mesenchymal stem cells (MSCs) or neurally differentiated MSCs (NMSCs) derived from bone marrow in a rat model of spinal cord injury (SCI). Sprague-Dawley rats were subjected to incomplete SCI using an NYU impactor to create a free drop contusion at the T9 level. The SCI rats were then classified into three groups; MSCs, NMSCs, and phosphate-buffered saline (PBS)-treated groups. The cells or PBS were administrated 1 week after SCI. Basso-Beattie-Bresnahan (BBB) locomotor rating scores were measured at 1-week intervals for 9 weeks. Somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs) were also recorded 8 weeks after transplantation. While transplantation of MSCs led to a clear tendency of motor recovery, NMSC-treated rats had significantly improved BBB scores and showed significantly shortened initial latency, N1 latency, and P1 latency of the SSEPs compared to PBS controls. In addition, 5-bromo-2-deoxyuridine (BrdU)-prelabeled MSCs costained for BrdU and glial fibrillary acidic protein (GFAP) or myelin basic protein (MBP) were found rostrally and caudally 5 mm each from the epicenter of the necrotic cavity 4 weeks after transplantation. These results suggest that neurally differentiated cells might be an effective therapeutic source for functional recovery after SCI.",
	pages = "1359-1368",
	url = "http://www.ingentaconnect.com/content/cog/ct/2009/00000018/00000012/art00008",
	doi = "doi:10.3727/096368909X475329",
	keyword = "Spinal cord injury, Transplantation, Mesenchymal stem cells, Neural differentiation, Functional recovery"
}