Current Status of Stem Cell Therapy for Liver Diseases

Authors: Souza, Bruno Solano de Freitas; Nogueira, Renata Campos; Oliveira, Sheilla Andrade de; de Freitas, Luiz Antonio Rodrigues; Lyra, Luiz Guilherme Costa; Ribeiro dos Santos, Ricardo; Lyra, Andre Castro; Soares, Milena Botelho Pereira

Source: Cell Transplantation, Volume 18, Number 12, 2009 , pp. 1261-1279(19)

Publisher: Cognizant Communication Corporation

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Abstract:

Liver failure is one of the main causes of death worldwide and is a growing health problem. Since the discovery of stem cell populations capable of differentiating into specialized cell types, including hepatocytes, the possibility of their utilization in the regeneration of the damaged liver has been a focus of intense investigation. A variety of cell types were tested both in vitro and in vivo, but the definition of a more suitable cell preparation for therapeutic use in each type of liver lesions is yet to be determined. Here we review the protocols described for differentiation of stem cells into hepatocytes, the results of cell therapy in animal models of liver diseases, as well as the available data of the clinical trials in patients with advanced chronic liver disease.

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Keywords: Liver diseases; Liver regeneration; Stem cells; Hepatocytes

Document Type: Research article

DOI: http://dx.doi.org/10.3727/096368909X470522

Publication date: 2009-12-01

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Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.

Current Status of Stem Cell Therapy for Liver Diseases

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