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Primate Adult Brain Cell Autotransplantation, a Pilot Study in Asymptomatic MPTP-Treated Monkeys
Authors: Brunet, Jean-François; Redmond, D. Eugene; Bloch, Jocelyne
Source: Cell Transplantation, Volume 18, Number 7, 2009 , pp. 787-799(13)
Publisher: Cognizant Communication Corporation
Abstract:
Autologous brain cell transplantation might be useful for repairing lesions and restoring function of the central nervous system. We have demonstrated that adult monkey brain cells, obtained from cortical biopsy and kept in culture for a few weeks, exhibit neural progenitor characteristics that make them useful for brain repair. Following MPTP treatment, primates were dopamine depleted but asymptomatic. Autologous cultured cells were reimplanted into the right caudate nucleus of the donor monkey. Four months after reimplantation, histological analysis by stereology and TH immunolabeling showed that the reimplanted cells successfully survived, bilaterally migrated in the whole striatum, and seemed to have a neuroprotection effect over time. These results may add a new strategy to the field of brain neuroprotection or regeneration and could possibly lead to future clinical applications.Keywords: Adult brain cells; Autograft; MPTP-treated monkeys
Document Type: Research article
DOI: http://dx.doi.org/10.3727/096368909X470847
Affiliations: 1: Department of Neurosurgery, Lausanne University Hospital, 1011 Lausanne, Switzerland. Jean-Francois.Brunet@chuv.ch
Publication date: 2009-07-01
- Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.
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- In this Subject: Anatomy & Physiology , Biology , Biotechnology , Pharmacology , Surgery
- By this author: Brunet, Jean-François ; Redmond, D. Eugene ; Bloch, Jocelyne
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