Beneficial Effect of the Nonpeptidyl Low Molecular Weight Radical Scavenger IAC on Cultured Human Islet Function

Authors: Mancarella, Rita; Del Guerra, Silvia; Masini, Matilde; Bugliani, Marco; Valgimigli, Luca; Pedulli, Gian Franco; Paolini, Moreno; Canistro, Donatella; Armando, Andrea; Soleti, Antonio; Filipponi, Franco; Mosca, Franco; Boggi, Ugo; Del Prato, Stefano; Marchetti, Piero; Lupi, Roberto

Source: Cell Transplantation, Volume 17, Numbers 10-11, October 2008 , pp. 1271-1276(6)

Publisher: Cognizant Communication Corporation

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Abstract:

We examined a possible protective effect of the nonpeptidyl low molecular weight radical scavenger IAC [bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decanedioate di-hydrochloride] on isolated human islet cells against isolation and culture oxidative stress. Islets isolated from pancreases of nondiabetic multiorgan donors by collagenase digestion were purified by density gradient centrifugation. After the isolation, islets were either exposed or not exposed for 7 days to 10 μmol/L IAC. We found that IAC markedly reduced oxidative stress and ameliorated islets function. These results suggest that the use of IAC could be an interesting pharmacological approach for the treatment of the islets before transplantation.

Keywords: Antioxidants; Human pancreatic islet; Islet transplantation; Oxidative stress

Document Type: Research Article

DOI: http://dx.doi.org/10.3727/096368908787236639

Publication date: October 1, 2008

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  • Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.

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