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In Vivo Tracking of Human Mesenchymal Stem Cells in Experimental Stroke

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Abstract:

To understand the fates of human mesenchymal stem cells (hMSCs) following transplantation into a rodent model of middle cerebral artery occlusion (MCAo), magnetic resonance imaging (MRI) techniques were employed. hMSCs were labeled with ferumoxides (Feridex┬«)–protamine sulfate complexes, which were visualized and examined by MRI up to 10 weeks following transplantation. Migration of the transplanted cells to the infarcted area was further confirmed by histological methods. We found that the hMSCs transplanted in MCAo models possess the capacity to migrate to the infarcted area extensively in both ipsilateral and contralateral injections, exhibiting a pathotropism. We also analyzed the detailed migration patterns of transplanted hMSCs. We speculate that the extensive migratory ability of hMSCs may represent a therapeutic potential for developing efficient cell transplantation strategies in stroke.

Keywords: Human mesenchymal stem cells (hMSCs); Magnetic resonance imaging (MRI); Middle cerebral artery occlusion (MCAo); Migration

Document Type: Research Article

DOI: http://dx.doi.org/10.3727/000000007783472381

Affiliations: 1: MRI Team, Korea Basic Science Institute, Ochang, Korea 2: CHA Stem Cell Institute, Pochon CHA University College of Medicine, Seoul, Korea 3: CHA Stem Cell Institute, Pochon CHA University College of Medicine, Seoul, Korea, Stem Cell Therapy Institute, CHA Biotech Co., Ltd., Seoul, Korea 4: Department of Pharmacology, Ajou University School of Medicine, Suwon, Gyeonggi-do, Korea

Publication date: October 1, 2007

More about this publication?
  • Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.

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