Factors Influencing the Loss of β-Cell Mass in Islet Transplantation

Authors: Emamaullee, Juliet A.¹; Shapiro, A. M. James²

Source: Cell Transplantation, Volume 16, Number 1, 2007 , pp. 1-8(8)

Publisher: Cognizant Communication Corporation

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Abstract:

Recent advances in clinical islet transplantation have clearly demonstrated that this procedure can provide excellent glycemic control and often insulin independence in a population of patients with type 1 diabetes. A key limitation in the widespread application of clinical islet transplantation is the requirement of 10,000 islet equivalents/kg in most recipients, generally derived from two or more cadaveric donors. It has been determined that a majority of the transplanted islets fail to engraft and become fully functional. In this review article, the factors that contribute to this early loss of islets following transplantation are discussed in depth.

Keywords: Islet transplantation; Apoptosis; Hypoxia; Revascularization; IBMIR

Document Type: Review article

Affiliations: 1: Department of Surgery, University of Alberta, Edmonton, AB Canada 2: *Department of Surgery, University of Alberta, Edmonton, AB Canada, Clinical Islet Transplant Program, University of Alberta, Edmonton, AB Canada

Publication date: 2007-01-01

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Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.

Factors Influencing the Loss of β-Cell Mass in Islet Transplantation

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