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Tissue Engineering and the Challenges Within

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Researchers face many challenges, both scientific and societal, in the field of tissue engineering. Herein we discuss the challenges in material design, selection of therapeutic cell source, the in vitro culturing of cells and materials, and finally the integration of the cultured construct into the body. We focus special attention on a new approach to the design of a biomaterial that would bridge synthetic and biologic materials seamlessly. The scaffolds we have developed serve as a transitional material between biotic and abiotic systems.
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Keywords: Biomaterials; Cell source; Gradient scaffolds; Tissue engineering

Document Type: Research Article

Affiliations: McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA

Publication date: 2006-03-01

More about this publication?
  • Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.

    Cell Transplantation is now being published by SAGE. Please visit their website for the most recent issues.

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