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Ectopic Ossification in the Scar Tissue of Rats With Myocardial Infarction

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Abstract:

We describe the occurrence of bone-like formations in the left ventricular wall of infarcted rats treated or not with bone marrow cells injected systemically or locally into the myocardium. The incidence of ectopic calcification in hearts has been reported in rare cases in children with infarcts without previous coronary artery disease. Recently, ventricular calcification has been correlated with unselected bone marrow cell transplantation into infarcted rat hearts. Echocardiographic analysis of large infarction in rats frequently reveals the presence of echogenic structures in the left ventricular wall, sometimes projecting to the lumen of the chamber. The histological examination of these echogenic structures exhibited bone, cartilage, and marrow-like formations extending from the collagen-rich matrix of the ventricle wall. Microanalytical techniques verified the presence of hydroxyapatite in the mineral phase. Ossification was found in 25 out of 30 hearts evaluated 90 days postinfarct, being observed in 14 out of 17 animals submitted to cell therapy and in 11 out of 13 infarcted rats not submitted to cell therapy. Our study indicates that chondro-osteogenic differentiation can take place in the pathological rat heart independent of animal treatment with marrow cells.

Keywords: Correlative microscopy; Ectopic ossification; Myocardial infarction; Osteogenesis

Document Type: Research Article

DOI: http://dx.doi.org/10.3727/000000006783981864

Affiliations: 1: Instituto de Biofísica Carlos Chagas Filho UFRJ-CCS, Bloco G, Ilha do Fundão, Rio de Janeiro, Brasil 2: Ecodata Exames Médicos LTDA, Rio de Janeiro, Brasil 3: Instituto de Ciências Biomédicas UFRJ-CCS, Bloco F, Ilha do Fundão, Rio de Janeiro, Brasil 4: Departamento de Ciências Fisiológicas UFES, Vitória, Brasil 5: *Instituto de Biofísica Carlos Chagas Filho UFRJ-CCS, Bloco G, Ilha do Fundão, Rio de Janeiro, Brasil §Instituto Nacional de Cardiologia Laranjeiras, Rio de Janeiro, Brasil

Publication date: May 1, 2006

More about this publication?
  • Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.

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