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The Fetal Dermal But Not Loose Fascial Mesenchymal Cells Possess Regenerative Activity of Dermal Structure

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Abstract:

Fetal skin possesses a regenerative activity until certain developmental stages. However, the origin of cells that regenerate dermis after wounding has not been clarified yet. In the present study we located the origin of cells that reconstruct fetal dermal structure by histological examination and by marking cells in the loose fascia. Next we evaluated the regenerative activity of fetal dermal mesenchymal cells by cotransplanting with fetal epidermal cells onto the skin defect of scid mice. We conclude that fetal dermal mesenchymal cells but not loose fascial cells possess regenerative activity even on the environment in scid mice.

Keywords: Dermal; Fetal wound healing; Regeneration; scid mouse

Document Type: Research Article

DOI: http://dx.doi.org/10.3727/000000005783982729

Affiliations: 1: Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjukuku, Tokyo, 160-8582 Japan 2: Molecular Pathology, Graduate School of Tokyo Medical and Dental University, Tokyo, 113-8549 Japan 3: Department of Plastic and Reconstructive Surgery, National Tokyo Medical Center, Tokyo, 152-8902 Japan 4: Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi Shinjukuku, Tokyo, 160-8582 Japan

Publication date: September 1, 2005

More about this publication?
  • Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.
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