BRIEF COMMUNICATION Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing Cells
Abstract:Intracerebral delivery of hCNTF has shown considerable neuroprotective potential in animal models of Huntington’s disease (HD). The present study describes the relationship between a range of hCNTF doses and the resulting behavioral and neurochemical (striatal ChAT and GAD activity) protection in a rodent model of HD. Encapsulated BHK delivering a range of hCNTF doses were implanted into the lateral ventricle ipsilateral to an intrastriatal quinolinic acid (QA) injection. Results demonstrated a dose-dependent effect of hCNTF with complete, partial, and no observable neuroprotection occurring with preimplant doses of hCNTF of 30.8, 8.6, and 0.8–2.1 ng hCNTF/24 h, respectively. These data continue to support the use of cellular delivery of hCNTF for HD and will facilitate the optimization of this approach in the clinical situation.
Document Type: Research Article
Affiliations: LCT BioPharma, Inc., 241 Anan Wade Road, Glocester, RI 02857
Publication date: 2004-01-01
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