BOOK REVIEW Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease Lazaros C. Triarhou (Kluwer Academic Publishers, Advances in Experimental Medicine and Biology series, vol. 517, 2003; includes bibliographical references and index; ISBN 0-306-47435-2)
Abstract:Parkinson’s disease (PD) is a neurodegenerative disorder with onset occurring in middle to later life. It is named after the British physician Dr. James Parkinson, who wrote the classic monograph, Essay on the shaking palsy, in 1817. This work described the cardinal signs and symptoms of one of the most common neurological disorders in the Western world—resting tremor, cogwheel rigidity, bradykinesia, and postural instability. The basic neuropathology of the disease was established in the first two decades of the 20th century. It is still not known why the pigmented melanin-containing, dopamine-producing neurons in the substantia nigra pars compacta undergo selective and progressive degeneration, resulting in severe secondary depletion of dopamine stores in the caudate and putamen (neostriatum). It is estimated that depletion of total dopamine stores must exceed 50–75% before symptoms appear (7).
Document Type: Book Review
Affiliations: Center of Excellence for Aging and È Brain Repair Department of Neurosurgery, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612
Publication date: January 1, 2004
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