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BOOK REVIEW Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease Lazaros C. Triarhou (Kluwer Academic Publishers, Advances in Experimental Medicine and Biology series, vol. 517, 2003; includes bibliographical references and index; ISBN 0-306-47435-2)

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Abstract:

Parkinson’s disease (PD) is a neurodegenerative disorder with onset occurring in middle to later life. It is named after the British physician Dr. James Parkinson, who wrote the classic monograph, Essay on the shaking palsy, in 1817. This work described the cardinal signs and symptoms of one of the most common neurological disorders in the Western world—resting tremor, cogwheel rigidity, bradykinesia, and postural instability. The basic neuropathology of the disease was established in the first two decades of the 20th century. It is still not known why the pigmented melanin-containing, dopamine-producing neurons in the substantia nigra pars compacta undergo selective and progressive degeneration, resulting in severe secondary depletion of dopamine stores in the caudate and putamen (neostriatum). It is estimated that depletion of total dopamine stores must exceed 50–75% before symptoms appear (7).

Document Type: Book Review

DOI: http://dx.doi.org/10.3727/000000004772664932

Affiliations: Center of Excellence for Aging and È Brain Repair Department of Neurosurgery, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612

Publication date: January 1, 2004

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  • Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.
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