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Evaluation of an MRI-Based Protocol for Cell Implantation in Four Patients With Huntington’s Disease

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Abstract:

The purpose of this study was to evaluate our surgical protocol for the preparation and delivery of suspensions of fetal tissue into the diseased human brain. We implanted suspensions of human fetal striatal anlage into the right caudate and putamen of four patients with Huntington’s disease. Postoperative 3 tesla MR imaging confirmed accurate graft placement. Variability in graft survival was noted and the MR signal changes over 6 months revealed persistent hyperintense signal on T2-weighted images. Our results are consistent with those described by other groups and indicate that our surgical protocol is safe, accurate, and reproducible

Keywords: Human cell transplant; Huntington’s disease; MRI

Document Type: Research Article

DOI: http://dx.doi.org/10.3727/000000003108747316

Affiliations: 1: *Academic Department of Neurosurgery, Addenbrooke’s Hospital and the University of Cambridge, Cambridge 2: †Wolfson Brain Imaging Centre, Addenbrooke’s Hospital and the University of Cambridge, Cambridge 3: ‡University Department of Radiology, Addenbrooke’s Hospital and the University of Cambridge, Cambridge 4: §University Department of Anaesthesia, Addenbrooke’s Hospital and the University of Cambridge, Cambridge 5: ¶National Institute for Neurology and Neurosurgery Queens Square, London

Publication date: December 1, 2002

More about this publication?
  • Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.
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