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COMMENTARY Standardized Embryonic Tissue Collection and Hibernation Procedures, and MRI-Based Graft Assessment: Advancing Neural Transplantation Therapy for Huntington’s Disease

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Abstract:

Neural transplantation is an effective experimental therapeutic option for neurodegenerative disorders, including Huntington’s and Parkinson’s disease. The advent of stem cells could potentially enhance logistical concerns and circumvent ethical concerns on the use of fetal tissues for transplantation. For example, the feasibility of bone marrow or hematopoetic stem cells has been recently investigated. However, controversy exists on the ability of these stem cells to transdifferentiate into neurons following transplantation (1,2,4,6). With this current debate on the potential of bone marrow and hematopoetic cells as a source for progenitor cells (i.e., neurons), fetal tissues remain the best option for neural transplantation. Successful neural transplant depends on the quality of donor tissue, specifically, that appropriate tissue sites have been isolated and their viability assured. With several ongoing clinical trials, a possibility for variability in reported results and data interpretation exists. In this issue of Cell Transplantation, Rosser and colleagues (5) propose a standardization of tissue collection based on an elaborate staging and dissection procedures. Embryonic fetal embryos are appropriately staged. A sensitive abdominal ultrasound approach allows identification of specific tissue sites, which are collected using a low suction protocol.

Document Type: Miscellaneous

DOI: http://dx.doi.org/10.3727/000000003108747235

Affiliations: Department of Neurology, Medical College of Georgia, and Research and Affiliations Service Line, Agusta VAMC, Augusta, GA 30912

Publication date: December 1, 2002

More about this publication?
  • Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.
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