@article {Berney:2001:0963-6897:633,
	author = "Berney T. and Molano R.D. and Pileggi A. and Cattan P. and Vizzardelli C. and Ricordi C. and Inverardi L.",
	title = "Absence of CSF-1-Dependent Macrophages Does Not Improve Function of Transplanted Islets of Langerhans",
	journal = "Cell Transplantation",
	volume = "10",
	number = "7",
	year = "2001",
	abstract = "<P>A role of macrophage-mediated inflammatory events in early islet graft loss is increasingly acknowledged. Osteopetrotic mice (op/op) have a complete absence of CSF-1, and thus of most tissue macrophages. We have investigated whether the absence of CSF-1-dependent macrophages in the graft itself or at the transplant site could decrease the delay to function of a syngeneic marginal islet mass. Islets transplanted into op/op or control recipients reversed diabetes in 59 days vs. 10 days (<I>p</I> = 0.28, NS). Islets isolated from op/op or control mice reversed diabetes in 11 days vs. 10 days. IL-1 and TNF-<IMG SRC="/iso-ents/isogrk1/agr-s.gif" ALT="agr"> release by cultured islets was markedly decreased for op/op islets compared with control islets (IL-1: 0 vs. 4.2 pg/ml, <I>p</I> = 0.07; TNF-<IMG SRC="/iso-ents/isogrk1/agr-s.gif" ALT="agr">: 67 vs. 311 pg/ml, <I>p</I> = 0.002). In contrast, IL-6 release by op/op islets was significantly increased (11.1 vs. 4.3 ng/ml, <I>p</I> = 0.006). CSF-1-dependent tissue macrophages may not be critical in the inflammatory insult to islet transplants. Alternate patterns of intraislet release of deleterious proinflammatory cytokines may exist.</P>",
	pages = "633-637",
	url = "http://www.ingentaconnect.com/content/cog/ct/2001/00000010/00000007/ct244",
	keyword = "Key words: Islet transplantation; Islet primary no"
}