P1GT-saporin fusion protein: a potential anti-angiogenic agent

Authors: Chiaramonte R.1; Polizzi D.2; Bartolini E.; Petroni D.; Comi P.

Source: Anti-Cancer Drug Design, Volume 12, Number 8, 1997 , pp. 649-657(9)

Publisher: Cognizant Communication Corporation

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Abstract:

Vascularization is an important step in tumor growth and metastasis. Tumor neovascularization can be considered, therefore, as a good target for antineoplastic therapy. In order to target saporin, a powerful plant toxin, in proximity of the tumor we fused the saporin coding sequence to that for placental growth factor-2 (P1GF-2). P1GF is an angiogenic factor involved in tumor neovascularization. The fusion protein P1GF-2-saporin was obtained by transient transfection of mammalian cells and released in the culture medium as a 57.5 kDa polypeptide. Selectivity and cytotoxic activity are reported as a preliminary step towards the evaluation of its in vivo antitumor activity.

Key words: anti-angiogenesis/anti-cancer/fusion protein/mitotoxin/P1GF/saporin

Document Type: Research article

Affiliations: 1: Corresponding author 2: Instituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, Milan, Italy

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