HHV-6 and Seizures
Authors: Yamashita, Nobuko; Morishima, Tsuneo
Source: Herpes, Volume 12, Number 2, 2005 , pp. 46-49(4)
Publisher: Cambridge Medical Publications
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Abstract:
Human herpes virus-6 (HHV-6) is a ubiquitous virus, but one that can induce various neurological diseases. Recently, several seizures have been reported as new HHV-6-associated diseases based on virological analysis. Neonates who are perinatally infected with HHV-6 can develop afebrile seizures, which are considered to be exanthem subitum (ES) in the neonatal period. Infants with ES also tend to develop atypical febrile seizures. After primary infection, HHV-6 commonly establishes latency in the central nervous system (CNS) and sometimes reactivates in the hippocampus, causing limbic encephalitis and temporal lobe epilepsy. These HHV-6-associated CNS diseases due to virus reactivation can occur in both immunocompromised and immunocompetent hosts. This article summarizes HHV-6-associated seizures during childhood.Keywords: HUMAN HERPES VIRUS-6; SEIZURE; NEONATAL SEIZURE; FEBRILE SEIZURE; TEMPORAL LOBE EPILEPSY; ENCEPHALITIS; ENCEPHALOPATHY
Document Type: Research article
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