Synergistic Interactions between Herpes Simplex Virus Type-2 and Human Immunodeficiency Virus Epidemics
Author: Wald, Anna
Source: Herpes, Volume 11, Number 3, 2004 , pp. 70-76(7)
Publisher: Cambridge Medical Publications
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Abstract:
The high prevalence and incidence of herpes simplex virus (HSV-2) infection among the areas of the world most affected by the HIV epidemic has focused attention on the interactions between the two viruses. HSV-2 increases the risk of HIV acquisition two-fold; its effect on HIV transmission is less defined. As HSV-2 is the most common genital ulcer disease worldwide, the risk of HIV attributable to HSV-2 is likely to be considerable. HSV-2, through chronic antigenic stimulation, may also increase the risk of HIV progression. In turn, HIV alters the natural history of HSV-2. People with both infections have higher rates of genital HSV-2 shedding, and are likely to be more infectious for both infections. Ongoing clinical trials hope to define the role of HSV-2 in HIV transmission and acquisition more accurately.Keywords: HERPES SIMPLEX VIRUS-2; HUMAN IMMUNODEFICIENCY VIRUS
Document Type: Research article
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