Hypophosphatemia in Cats After Renal Transplantation

Authors: PASTER, ERIN R.; MEHL, MARGO L.; KASS, PHILIP H.; GREGORY, CLARE R.

Source: Veterinary Surgery, Volume 38, Number 8, December 2009 , pp. 983-989(7)

Publisher: Wiley-Blackwell

Abstract:

Objective

To report the prevalence of hypophosphatemia after renal transplantation in a historical cohort of cats. Design

Case series. Animals

Cats (n=86) that received a renal allograft. Methods

Medical records (January 200-June 2006) were reviewed. Signalment, clinical signs, pre- and postoperative diet, pre- and postoperative clinicopathologic variables, renal histopathology, and outcome were retrieved. Prevalence, onset, duration, treatment and associated clinical signs of hypophosphatemia were recorded. A χ² test was used to compare hemolysis frequency between cats with normal serum phosphorus concentration or a single spurious low serum phosphorus concentration for <24 hours duration (group 1) and confirmed hypophosphatemia for >24 hours (group 2). A Cox proportional hazards model was used to evaluate the effects of hypophosphatemia on survival while controlling for other potentially confounding variables (age, sex, weight, body condition score, and pre- and 24 hours postoperative clinicopathologic variables). Results

Eighty-six cats (mean age, 7.7 years) were identified. Hypophosphatemia occurred in 32 cats (37%), with a median onset of 2 days and median duration of 4 days. Treatment was initiated in 48 (56%) of hypophosphatemic cats. Survival and hemolysis frequency was not significantly different between groups, and no risk factors were identified. Conclusion

Hypophosphatemia occurs in cats after renal transplantation and does not affect survival. Clinical Relevance

The clinical importance of hypophosphatemia in renal transplant recipients remains unknown.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1532-950X.2009.00588.x

Affiliations: 1: William R. Pritchard Veterinary Medical Teaching Hospital, and the Departments of Surgical and Radiological Sciences, and Population Health and Reproduction, University of California-Davis, Davis, CA.

Publication date: 2009-12-01

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