IngentaConnect Ocular effects of topical 0.03% bimatoprost solution in normotens...

Authors: Regnier, Alain¹; Lemagne, Capucine¹; Ponchet, Alice¹; Cazalot, Guillaume¹; cordet, Didier²; Gelatt, Kirk N.³

Source: Veterinary Ophthalmology, Volume 9, Number 1, January 2006 , pp. 39-43(5)

Publisher: Blackwell Publishing

Abstract:

Objective

The current study was undertaken to evaluate the effects of topically applied bimatoprost, an ocular hypotensive lipid, on intraocular pressure (IOP) and pupil size (PS) in healthy cats. Animal studied

Nine European Shorthair cats free from clinically relevant ocular abnormalities were used in the study. Procedures

Pretreatment baseline measurements of IOP and PS were obtained bilaterally at 8 am, 2 pm, and 8 pmfor five consecutive days (days 1 to 5). Then the cats received one drop twice daily (10amand 6 pm) of bimatoprost ophthalmic solution 0.03% (Lumigan™, Allergan Inc., Irvine, CA USA), in one randomly selected eye and one drop of artificial tears in the fellow eye (control eye) for 5 days (days 6 to 10). Values for IOP and PS were obtained under the same conditions as in the pretreatment phase. The potential for ocular irritation following bimatoprost application was also evaluated. Results

During the pretreatment period, the mean IOP and mean PS were not significantly different between the eyes subsequently treated with bimatoprost and those subsequently determined as controls. During the treatment period, the mean IOP in bimatoprost-treated eyes was not significantly lower than in control eyes (14.2 ± 2.3 vs. 14.5 ± 2.8 mmHg). Mean IOP in control eyes was not significantly changed at any time during the study period. A marked reduction of PS was seen in all bimatoprost-treated eyes, but no other clinically relevant side effects were observed. Conclusion

Twice daily topical applications of bimatoprost produced miosis but had no significant effect on IOP in healthy cats.

Keywords: bimatoprost; cat; intraocular pressure; ocular effects; pupil size

Document Type: Research article

DOI: 10.1111/j.1463-5224.2005.00435.x

Affiliations: 1: Department of Clinical Sciences and 2: Unit Research INRA/ENVT 181 of Experimental Physiology and Pharmacology, National Veterinary School, 31076 Toulouse, France; and 3: Comparative Ophthalmology, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Gainesville, Florida 32610 USA

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Ocular effects of topical 0.03% bimatoprost solution in normotensive feline eyes