A Checklist for Medication Compliance and Persistence Studies Using Retrospective Databases

Authors: Peterson, Andrew M.; Nau, David P.¹; Cramer, Joyce A.²; Benner, Josh³; Gwadry-Sridhar, Femida⁴; Nichol, Michael⁵

Source: Value in Health, Volume 10, Number 1, January/February 2007 , pp. 3-12(10)

Publisher: Wiley-Blackwell

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Abstract:

The increasing number of retrospective database studies related to medication compliance and persistence (C&P), and the inherent variability within each, has created a need for improvement in the quality and consistency of medication C&P research. This article stems from the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) efforts to develop a checklist of items that should be either included, or at least considered, when a retrospective database analysis of medication compliance or persistence is undertaken. This consensus document outlines a systematic approach to designing or reviewing retrospective database studies of medication C&P. Included in this article are discussions on data sources, measures of C&P, results reporting, and even conflict of interests. If followed, this checklist should improve the consistency and quality of C&P analyses, which in turn will help providers and payers understand the impact of C&P on health outcomes.

Keywords: compliance; guidelines; persistence; retrospective databases

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1524-4733.2006.00139.x

Affiliations: 1: University of Michigan, Ann Arbor, MI, USA; 2: Yale University, West Haven, CT, USA; 3: ValueMedics Research, LLC, Falls Church, VA, USA; 4: McMaster University, London, ON, Canada; 5: University of Southern California, Los Angeles, CA, USA

Publication date: 2007-01-01