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Use of C-reactive protein to predict outcome in dogs with systemic inflammatory response syndrome or sepsis

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Abstract Background–

There is a high mortality rate in patients with systemic inflammatory response syndrome (SIRS) or sepsis. Therefore, an early diagnosis and prognostic assessment is important for optimal therapeutic intervention. The objective of the study was to evaluate if baseline values and changes in serum C-reactive protein (CRP) might predict survival in dogs with SIRS and sepsis. Design–

Prospective study; July 2004 to July 2005. Setting–

Small Animal Clinic, Berlin, Clinic of Small Animal Medicine, Munich. Animals–

Sixty-one dogs. Measurements and Main Results–

For the CRP analysis blood was drawn on day 0, 1, and 2; CRP was measured using a commercial ELISA test kit. Thirteen dogs suffered from nonseptic SIRS and 48 dogs from sepsis. The 14-day survival rate was 61% (69% nonseptic SIRS, 58% sepsis). Serum CRP was higher in sick dogs compared with controls (P<0.001). Over the 3-day period surviving dogs (n=31) displayed a significantly greater decrease in CRP than nonsurvivors (n=10) (P=0.001). No correlation was found between the initial CRP concentrations and the survival rate. The changes in CRP corresponded to the survival rate (P=0.01). Conclusion–

There was no significant relationship between the survival rate in dogs with nonseptic SIRS or sepsis and the initial serum CRP concentrations. There was a correlation between decreasing CRP concentrations and recovery from disease. However, the changes in CRP concentrations over a 3-day period correctly predicted survival in 94% of dogs and death in 30% of the dogs (false positive rate 22%).
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Keywords: CRP; acute phase proteins; prognosis; survival prediction; systemic inflammation

Document Type: Research Article

Affiliations: 1: Small Animal Clinic, Freie Universität Berlin, Berlin, Germany, 2: Clinic of Small Animal Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany, 3: Institute for Biometrics and Data Processing, Freie Universität Berlin, Berlin, Germany, 4: Institute of Nutritional Science, University of Potsdam, Potsdam, Germany, 5: Institute for Animal Physiology, Ludwig-Maximilians-University of Munich, Munich, Germany

Publication date: 2009-10-01

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