Superficial necrolytic dermatitis associated with extrapancreatic glucagonoma in a dog

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Abstract:

Abstract

An 11-year-old Shih Tzu presented with crusting and erythema, mainly on the abdomen and the root of the tail. Based on histopathological findings, blood examinations and necropsy findings, the condition was diagnosed as superficial necrolytic dermatitis associated with a glucagon-secreting extrapancreatic neuroendocrine tumour. Gross necropsy revealed tumour invasion into the spleen, liver, adrenal glands and mesenteric lymph nodes. Immunohistochemical analysis of the neoplastic cells revealed that the tumour was a glucagonoma, consistent with earlier findings of persistent glucagonaemia and hypoaminoacidaemia.

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3164.2008.00729.x

Affiliations: 1: Laboratory of Veterinary Internal Medicine 2: Laboratory of Veterinary Parasitology 3: Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan

Publication date: February 1, 2009

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