IngentaConnect A randomized controlled trial of misoprostol monotherapy for cani...

Authors: Olivry T.¹; Dunston S.M.¹; Rivierre C.¹; Jackson H.A.¹; Murphy K.M.¹; Peters E.²; Dean G.A.²

Source: Veterinary Dermatology, Volume 14, Number 1, February 2003 , pp. 37-46(10)

Abstract:

In this blinded randomized placebo-controlled trial, 20 dogs with atopic dermatitis (AD) were given placebo (8 dogs) or misoprostol (12 dogs) at 5 µg kg^-1, orally, three times daily for 3 weeks. Administration of the active drug, but not of placebo, led to a significant decrease in lesional and pruritus scores. The median reduction from baseline of both scores was

30%. Misoprostol therapy did not lead to decreases of dermal cell counts or skin tumour necrosis factor (TNF) alpha

mRNA copy numbers that were significantly different from those of placebo. Skin TNF alpha

protein production, assessed using indirect immunofluorescence, decreased or remained unchanged in dogs receiving misoprostol. In contrast, post treatment TNF alpha

fluorescence scores were higher in all but two dogs given placebo. The changes from baseline of TNF alpha

fluorescence scores did not correlate significantly with those of lesional or pruritus indices. These observations confirm the modest efficacy of misoprostol for treatment of canine AD and suggest that its mild anti-allergic effects are not associated with either inhibition of inflammatory cell emigration or TNF alpha

production.

Keywords: allergy; atopic dermatitis; atopy; canine; misoprostol; randomized controlled trial; tumour necrosis factor alpha

Document Type: Research article

DOI: 10.1046/j.1365-3164.2003.00323.x

Affiliations: 1: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA 2: Department of Molecular Biosciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA

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A randomized controlled trial of misoprostol monotherapy for canine atopic dermatitis: effects on dermal cellularity and cutaneous tumour necrosis factor-alpha