Abstract:

The post-antibiotic effect in vitro (PAE) of cephalexin was determined according to a broth dilution method against 5 isolates of Staphylococcus intermedius obtained from cases of canine pyoderma. Two durations of exposure and 3 concentrations were tested. The PAE increased when time of exposure or concentration increased. The mean PAE ranged from 0.7 to 3.3 h. The PAE of cephalexin against Staph-ylococcus intermedius may be clinically relevant when selecting a dosage regimen to treat pyoderma in dogs.

Keywords: cephalexin; dog; post-antibiotic effect; pyoderma; Staphylococcus intermedius

Document Type: Short communication

DOI: 10.1046/j.1365-3164.1999.00184.x

Affiliations: 1: Virbac, BP 27, 06511 Carros Cedex, France 2: Unité de Pathologie Infectieuse, Ecole Nationale Vétérinaire, BP 40706, 44307 Nantes Cedex 03, France