Post-antibiotic effect of cephalexin against isolates of Staphylococcus intermedius obtained from cases of canine pyoderma

Authors: Bousquet, E.¹; Ganiere, J.-P.²; Ruvoen, N.²; Larrat, M.²

Source: Veterinary Dermatology, Volume 10, Number 3, September 1999 , pp. 253-255(3)

Publisher: Blackwell Publishing

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Abstract:

The post-antibiotic effect in vitro (PAE) of cephalexin was determined according to a broth dilution method against 5 isolates of Staphylococcus intermedius obtained from cases of canine pyoderma. Two durations of exposure and 3 concentrations were tested. The PAE increased when time of exposure or concentration increased. The mean PAE ranged from 0.7 to 3.3 h. The PAE of cephalexin against Staph-ylococcus intermedius may be clinically relevant when selecting a dosage regimen to treat pyoderma in dogs.

Keywords: cephalexin; dog; post-antibiotic effect; pyoderma; Staphylococcus intermedius

Document Type: Short communication

DOI: 10.1046/j.1365-3164.1999.00184.x

Affiliations: 1: Virbac, BP 27, 06511 Carros Cedex, France 2: Unité de Pathologie Infectieuse, Ecole Nationale Vétérinaire, BP 40706, 44307 Nantes Cedex 03, France

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