Ocular metastasis of a vaccine-associated fibrosarcoma in a cat

Authors: Cohen M.¹; Sartin E.A.²; Whitley E.M.²; Whitley R.D.¹; Smith A.N.¹; Brawner W.R.¹; Henderson R.¹; Behrend E.N.¹

Source: Veterinary and Comparative Oncology, Volume 1, Number 4, December 2003 , pp. 232-240(9)

Publisher: Wiley-Blackwell

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Abstract:

A 6-year-old, neutered male domestic shorthair cat was evaluated for a recurrent vaccine-associated fibrosarcoma. The cat had three excisions of the tumour prior to presentation and was referred for radiation therapy. Ten months following treatment with radiation therapy, the cat was presented again for a cloudy appearance to the eye. An exenteration was performed, and biopsy revealed fibrosarcoma. At the same time, two discrete pulmonary nodules were identified on thoracic radiographs. Two doses of doxorubicin (20 mg/m²) and cyclophosphamide (100 mg/m²) were administered intravenously 3 weeks apart. Despite treatment, the pulmonary nodule doubled in size. This case represents the first antemortem report of ocular metastasis of a vaccine-associated sarcoma and supports the highly aggressive nature of these tumours.

Keywords: cat; feline; metastasis; ocular; vaccine-associated fibrosarcoma

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1476-5810.2003.00031.x

Affiliations: 1: Comparative Oncology Program, Animal Cancer Treatment Unit, College of Veterinary Medicine, Auburn University, Auburn, AL, USA 2: Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA

Publication date: 2003-12-01