Human T‐cell leukemia virus type 1 infection worsens prognosis of hepatitis C virus‐related living donor liver transplantation
Severe and life‐threatening donor‐transmitted human T‐cell leukemia virus type 1 (HTLV‐1) infections after solid organ transplantation have been reported. However, in HTLV‐1‐infected recipients, graft and patient survival were not fully evaluated. A total of 140 patients underwent living donor liver transplantation (LDLT). Of these, 47 of 126 adult recipients showed indications of hepatitis C virus (HCV)‐related liver disease. The HTLV‐1 prevalence rate was 10 of 140 recipients (7.14%) and three of 140 donors (0.02%). In HCV‐related LDLT, graft and patient survival was worsened by HTLV‐1 infection in recipients (seven cases). The 1‐, 3‐, and 5‐year survival rates in the HCV/HTLV‐1‐co‐infected group were 67%, 32%, and 15%, respectively, and the corresponding rates in the HCV‐mono‐infected group were 80%, 67%, and 67%, respectively. Only the 5‐year survival rates were statistically significant (P = 0.04, log‐rank method). HTLV‐1 infection in recipients is also an important factor in predicting survival in HTLV‐1 endemic areas.
Document Type: Research Article
Affiliations: 1: Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan 2: Department of Transplantation and Digestive Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan 3: Central Diagnostic laboratory of Nagasaki University Hospital, Nagasaki, Japan
Publication date: 2012-04-01