Skip to main content

Human T‐cell leukemia virus type 1 infection worsens prognosis of hepatitis C virus‐related living donor liver transplantation

Buy Article:

$43.00 plus tax (Refund Policy)


Severe and life‐threatening donor‐transmitted human T‐cell leukemia virus type 1 (HTLV‐1) infections after solid organ transplantation have been reported. However, in HTLV‐1‐infected recipients, graft and patient survival were not fully evaluated. A total of 140 patients underwent living donor liver transplantation (LDLT). Of these, 47 of 126 adult recipients showed indications of hepatitis C virus (HCV)‐related liver disease. The HTLV‐1 prevalence rate was 10 of 140 recipients (7.14%) and three of 140 donors (0.02%). In HCV‐related LDLT, graft and patient survival was worsened by HTLV‐1 infection in recipients (seven cases). The 1‐, 3‐, and 5‐year survival rates in the HCV/HTLV‐1‐co‐infected group were 67%, 32%, and 15%, respectively, and the corresponding rates in the HCV‐mono‐infected group were 80%, 67%, and 67%, respectively. Only the 5‐year survival rates were statistically significant (P = 0.04, log‐rank method). HTLV‐1 infection in recipients is also an important factor in predicting survival in HTLV‐1 endemic areas.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1:  Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan 2:  Department of Transplantation and Digestive Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan 3:  Central Diagnostic laboratory of Nagasaki University Hospital, Nagasaki, Japan

Publication date: 2012-04-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more