Skip to main content

Preoperative treatment of a presensitized kidney transplant recipient with donor-derived transplant acceptance-inducing cells

Buy Article:

$51.00 plus tax (Refund Policy)



This report describes the case of patient FR, a 31-year-old recipient of a living-related kidney transplant from a donor against whom he was presensitized. Seventeen days prior to transplantation, a central venous infusion of transplant acceptance-inducing cells (TAICs) was administered to the patient. During the 27-month follow up, the patient experienced no acute rejection episodes under an immunosuppressive regime comprising anti-thymocyte globulin (ATG) induction, corticosteroids and tacrolimus. In a similar manner to the kidney transplant recipients treated preoperatively with TAICs in a previous study, patient FR achieved a state of donor-specific hypo-responsiveness. Most remarkably, the deliberate preoperative exposure of a sensitized patient to the sensitizing alloantigen did not heighten his response; on the contrary, after TAIC treatment and transplantation, HLA-specific antibodies were no longer detectable. The case of patient FR provides further evidence of the safety of pre-transplantation treatment with TAICs.

Keywords: TAIC; cell-based immunotherapy; tolerance; transplantation

Document Type: Case Report


Affiliations: 1:  Laboratory of Transplantation Research of the Clinic of General and Thoracic Surgery, University of Schleswig-Holstein, Kiel, Germany 2:  Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands 3:  Department of Nephrology, University Duisburg-Essen, Essen, Germany 4:  Department of Immunology, University of Schleswig-Holstein, Kiel, Germany 5:  Department of Nephrology, University of Schleswig-Holstein, Kiel, Germany 6:  Division of Experimental Surgery, Department of Surgery, University of Regensburg, Regensburg, Germany

Publication date: August 1, 2008


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more