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Graded function of CD80 and CD86 in initiation of T-cell immune response and cardiac allograft survival

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CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4), which have opposing functions in T-cell responses, share the two ligands, CD80 (B7-1) and CD86 (B7-2). To understand the functions of CD80 and CD86, respectively, CD80low dendritic cells (DCs) and CD86low DCs were prepared by using RNA interference. Then CD80 and CD86 functions were analysed by in vitro mixed lymphocyte reaction and cytokine production assay. Effect on cardiac allograft survival was assayed in vivo. In this study, graded stimulatory function of CD80 and CD86, stronger inhibition of proliferation, and stronger prolongation of transplant survival were observed when CD80 and CD86 were blocked simultaneously.

Keywords: CD80; CD86; dendritic cell; small interfering RNA

Document Type: Research Article


Affiliations: 1:  Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China 2:  Department of Immunology, and General Surgery, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA

Publication date: 2008-02-01

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