Bone mineral density, growth, pubertal development and other parameters in Brazilian children and young adults with sickle cell anaemia

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Abstract:

Abstract
Objectives

To evaluate the occurrence of low bone mineral density (BMD) and its relationship with clinical and laboratorial characteristics in children and young adults with sickle cell anaemia living in Northeast‐Brazil, and to assess the role of radiography in diagnosing low BMD.
Methods

Bone mineral density of lumbar spine was measured by dual energy X‐ray absorptiometry (DXA) in 27 patients with Sickle cell anaemia (SCA) aged 7–28 years. Clinical history, calcium and calorie intake, laboratory measurements, anthropometrics and pubertal development were assessed, and X‐rays were obtained. Z‐scores and T‐scores for weight, height, Body Mass Index (BMI) and BMD were calculated using age and gender matched reference data.
Results

Mean lumbar spine BMD Z‐scores and T‐scores were −1.81 SD in boys and −0.80 SD in girls. BMD Z‐scores were below ‐2 SD in 33.3% of girls and in 46.7% of boys. Low BMD (<−2 SD) occurred significantly more in patients with low height‐for‐age (P = 0.02), low weight‐for‐age (P = 0.001) and low BMI‐for‐age (P = 0.006). No significant relationships were found between BMD and other clinical and laboratory parameters. Radiography had a sensitivity of 75% and a specificity of 36% to detect low BMD, and was considered not useful in this context.
Conclusions

Patients with low height and/or low weight‐for‐age seem to be at high risk for developing low BMD.

Language: French

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/tmi.12211

Publication date: December 1, 2013

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