Skip to main content

Free Content Effect of HSV‐2 on population‐level trends in HIV incidence in Uganda between 1990 and 2007

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Abstract:

Abstract
Objective

To assess the long‐term effects of population‐level HSV‐2 infection on HIV incidence.
Methods

Data from a population‐based cohort in south‐western Uganda were used to estimate HIV incidence from 1990 to 2007. Stored blood samples were tested for HSV‐2, and the impact of HSV‐2 prevalence and incidence on HIV incidence was estimated by calculating population attributable fractions (PAFs). The association between population‐level annual HIV incidence and annual HSV‐2 incidence/prevalence was analysed using linear regression.
Results

HIV incidence declined over time among men, from 8.72/1000 person‐years (pyr) in 1990 to 4.85/1000 pyr in 2007 (P‐trend <0.001). In contrast, there was no decline in HIV incidence among women (4.86/1000 pyr in 1990 to 6.74/1000 pyr in 2007, P‐trend = 0.18). PAFs of incident HIV attributable to HSV‐2 were high (60% in males; 70% in females). There was no evidence of an association between long‐term trends in HIV incidence and HSV‐2 prevalence or incidence.
Conclusion

Assuming a causal relationship, a substantial proportion of new HIV infections in this population are attributable to HSV‐2. The study did not find an effect of HSV‐2 prevalence/incidence on trends in HIV incidence. HIV incidence did not vary much during the study period. This may partly explain the lack of association.

Language: French

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/tmi.12176

Publication date: October 1, 2013

bsc/tmih/2013/00000018/00000010/art00013
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more