If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Association of IL‐10 and CCL5 single nucleotide polymorphisms with tuberculosis in the Sudanese population

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Abstract
Objective

To investigate the genetic determinants for developing tuberculosis in Sudan.
Methods

Case study of 232 patients with tuberculosis and 206 healthy matched controls from Sudan. In the study population, three single nucleotide polymorphisms (SNPs) in the promoter regions of CCL5 and two in the promoter region of IL‐10 were genotyped using polymerase chain reaction and restriction fragment length polymorphism (PCR‐RFLP). These five SNPs influence the expression of these genes.
Results

There were significant differences in allele distribution for CCL5 ‐28 C/G (rs 2280788) and IL‐10 ‐592 A/C (rs1800872) in patients with tuberculosis compared with healthy controls.
Conclusion

This indicates that the genotypes obtained for CCL5 and IL‐10 are associated with an increased risk of developing active TB.

Language: French

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/tmi.12141

Publication date: September 1, 2013

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more