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Free Content Practical dosing of praziquantel for schistosomiasis in preschool‐aged children

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Abstract:

Abstract
Objective

Schistosomiasis is known to occur in preschool‐aged children, but achieving accurate dosing of praziquantel in its current form is challenging. While waiting for a paediatric formulation, there is a need to develop a means for using the available products to treat this age group. Current 600‐mg tablets are differently scored to give units of 150 mg (a quarter of a tablet) or 300 mg (half a tablet).
Methods

We examined several dosing schemes to dose accurately (40‐60 mg/kg) children aged 3–72 months (weight range 4–25 kg, based on available weight‐for‐age growth references from sub‐Saharan Africa and Brazil, n = 106,230).
Results

Adequate dosing can be achieved with formulations that can be split into four 150 mg quarters for children weighing 5 kg or more, and with tablets than can be split into two 300 mg halves for children weighing 10 kg or more. Giving ½ tablet for 5–7 kg; ¾ tablet for 8–10 kg; 1 tablet for 11–15 kg; 1 ½ tablet for 16–21 kg; and two tablets for 22–25 kg will have 100% of subjects correctly dosed within the target 40–60 mg/kg range.
Conclusions

Formulations that can be divided into four parts (to give 150 mg increments) are preferred for children weighing less than 11 kg; the same dosing can be applied with 600 mf praziquantel formulations that can be divided into four quarters or two halves from 11 kg body weight.

Language: French

Document Type: Research Article

DOI: https://doi.org/10.1111/tmi.12152

Publication date: 2013-09-01

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