Free Content Paediatric HIV care in sub‐Saharan Africa: clinical presentation and 2‐year outcomes stratified by age group

You have access to the full text article on a website external to ingentaconnect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Download Article:

Abstract:

Abstract
Objectives

To examine age differences in mortality and programme attrition amongst paediatric patients treated in four African HIV programmes.
Methods

Longitudinal analysis of data from patients enrolled in HIV care. Two‐year mortality and programme attrition rates per 1000 person‐years stratified by age group (<2, 2–4 and 5–15 years) were calculated. Associations between outcomes and age and other individual‐level factors were studied using multiple Cox proportional hazards (mortality) and Poisson (attrition) regression models.
Results

Six thousand two hundred and sixty‐one patients contributed 9500 person‐years; 27.1% were aged <2 years, 30.1% were 2–4, and 42.8% were 5–14 years old. At programme entry, 45.3% were underweight and 12.6% were in clinical stage 4. The highest mortality and attrition rates (98.85 and 244.00 per 1000 person‐years), and relative ratios (adjusted hazard ratio [aHR] = 1.92, 95% CI 1.56–2.37; incidence ratio [aIR] = 2.10, 95% CI 1.86–2.37, respectively, compared with the 5‐ to 14‐year group) were observed amongst the youngest children. Increased mortality and attrition were also associated with advanced clinical stage, underweight and diagnosis of tuberculosis at programme entry.
Conclusions

These results highlight the need to increase access, diagnose and provide early HIV care and to accelerate antiretroviral treatment initiation for those eligible. Adapted education and support for children and their families would also be important.

Language: French

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/tmi.12142

Publication date: September 1, 2013

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more