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Free Content Advances with vaccination against Neisseria meningitidis

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Abstract:

Abstract

In the last decade, meningococcal serogroup C conjugate vaccination programs have been demonstrated to be hugely successful with a truly impressive public health impact. In sub‐Saharan Africa, with the implementation of an affordable serogroup A conjugate vaccine, it is hoped that a similar public health impact will be demonstrated. Challenges still remain in the quest to develop and implement broadly protective vaccines against serogroup B disease. New, broad coverage vaccines against serogroup B are for the first time becoming available although little is known about their antibody persistence, effectiveness or effect on nasopharyngeal carriage. Enhanced surveillance following any potential vaccine introduction against serogroup B needs to be thoroughly implemented. The future now holds a distinct possibility, globally, for substantially decreasing meningococcal disease, regardless of infecting serogroup.

Language: English

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1365-3156.2012.03085.x

Affiliations: Vaccine Evaluation Unit, Health Protection Agency, Manchester Royal Infirmary, Manchester, UK

Publication date: 2012-12-01

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