Skip to main content

Free Content Procalcitonin and C‐reactive protein as predictors of blood culture positivity among hospitalised children with severe pneumonia in Mozambique

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library


Objectives  To evaluate the benefits of using procalcitonin (PCT) and C‐reactive protein (CRP) as pre‐screening tools to predict blood culture positivity among Mozambican children with clinical severe pneumonia (CSP).

Methods  586 children <5 years with CSP and no concurrent malaria fulfilled criteria to be included in the study groups. We determined PCT and CRP for all children with positive bacterial culture (BC+ group, n =84) and of a random selection of children with negative bacterial culture (BC− group, n =246).

Results  PCT and CRP levels were higher in the BC+ group than the BC− one (PCT: median 7.73 versus 0.48 ng/ml, P <0.001; CRP: 177.65 mg/l vs. 26.5 mg/l, P <0.001). In multivariate analysis, PCT was the only independent predictor of the group. To be used as pre‐screening tool, PCT presented higher specificities for predetermined sensitivities (≥85%) than CRP. Pursuing a sensitivity of 95%, PCT could reduce the need for bacterial culture by 49% and overall diagnosis costs by 7–35% [assuming variable costs for PCT measurement (ranging from 10 to 30 USD) and a fixed cost of 72.5 USD per blood culture].

Conclusions  Among hospitalised children with CSP and absence of concurrent malaria, PCT pre‐screening could help reduce the number of blood cultures and diagnosis costs by specifically targeting patients more likely to yield positive results.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Language: English

Document Type: Research Article

Affiliations: 1:  Centro de Investigaçaõ em Saúde da Manhiça, Manhiça, Mozambique 2:  Barcelona Centre for International Health Research, Universitat de Barcelona, Spain

Publication date: 2012-09-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more