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Free Content Endemic and opportunistic infections in Brazilian solid organ transplant recipients

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Abstract:

Summary

Objective  To evaluate the frequency and clinical features of endemic and other opportunistic infections in liver or kidney transplant recipients in four transplant centres in different geographical areas of Brazil.

Methods  Retrospective analysis of medical and laboratory records of four transplant centres on endemic and other opportunistic infections in liver or kidney transplant recipients. Analyses were performed with spss statistical software.

Results  From 2001 to 2006, 1046 kidney and 708 liver transplants were registered in all centres. The average age was 42 years. Among 82 (4.7%) cases with infections, the most frequent was tuberculosis (2.0%), followed by systemic protozoal infections (0.7%), toxoplasmosis (0.4%) and visceral leishmaniasis (0.3%). Systemic fungal infections occurred in 0.6%, of which 0.4% were cryptococcosis and 0.2% were histoplasmosis. Dengue was the only systemic viral infection and was registered in two cases (0.1%), of which one was classified as the classic form and the other as dengue haemorrhagic fever. Nocardiosis was described in one case (0.05%). The infectious agents most frequently associated with diarrhoea were Blastocystis sp., Schistosoma mansoni and Strongyloides stercoralis.

Conclusions  Opportunistic Infections in transplant patients have a wide spectrum and may vary from asymptomatic to severe infections with high mortality. A better understanding of the epidemiology of endemic pathogens and clinical manifestations can contribute to the establishment of an early diagnosis as well as correct treatment aimed at decreasing morbidity and mortality.

Language: English

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1365-3156.2011.02816.x

Affiliations: 1:  Infections in Immunocompromised Host Group, Hospital das Clínicas da Faculdade de Medicina, University of São Paulo, São Paulo, Brazil 2:  Alfa Gastroenterology Institute, Hospital das Clínicas da Faculdade de Medicina, University of Minas Gerais, Minas Gerais, Brazil 3:  Renal Transplantation Unit, Hospital Universitário Walter Cantídio, University of Ceará, Ceará, Brazil 4:  Renal Transplant Unit, Infectious Diseases Department, Hospital das Clínicas da Faculdade de Medicina, University of Uberlândia, Minas Gerais, Brazil 5:  Renal Transplant Unit, Urological Division, Hospital das Clínicas da Faculdade de Medicina, University of São Paulo, São Paulo, Brazil 6:  Liver Transplantation Division, Hospital das Clínicas da Faculdade de Medicina, University of São Paulo, São Paulo, Brazil

Publication date: 2011-09-01

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