Skip to main content

Free Content Resistance to first‐line tuberculosis drugs in three cities of Nigeria

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library



Objectives  To determine the levels of resistance to first‐line tuberculosis drugs in three cities in three geopolitical zones in Nigeria.

Methods  A total of 527 smear‐positive sputum samples from Abuja, Ibadan and Nnewi were cultured on BACTEC‐ MGIT 960. Drug susceptibility tests (DST) for streptomycin, isoniazid, rifampicin and ethambutol were performed on 428 culture‐positive samples on BACTEC‐MGIT960.

Results  Eight per cent of the specimens cultured were multi‐drug‐resistant Mycobacterium tuberculosis (MDR‐TB) with varying levels of resistance to individual and multiple first–line drugs. MDR was strongly associated with previous treatment: 5% of new and 19% of previously treated patients had MDR‐TB (OR 4.1 (95% CI 1.9–8.8), P = 0.001) and with young adult age: 63% of patients with and 38% without MDR‐TB were 25–34 years old (P = 0.01). HIV status was documented in 71%. There was no association between MDR‐TB and HIV coinfection (P = 0.9) and gender (P > 0.2 for both).

Conclusions¬† MDR‐TB is an emerging problem in Nigeria. Developing good quality drug susceptibility test facilities, routine monitoring of drug susceptibility and improved health systems for the delivery of and adherence to first‐ and second‐line treatment are imperative to solve this problem.

Language: English

Document Type: Research Article


Affiliations: 1:  Zankli Medical Centre, Abuja, Nigeria 2:  Liverpool School of Tropical Medicine, Liverpool, UK 3:  National Tuberculosis and Leprosy Control Programme, Abuja, Nigeria 4:  Tropical Medicine Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia 5:  University College Hospital, Ibadan, Nigeria 6:  Wuse General Hospital, Abuja, Nigeria 7:  Nnamdi Azikiwe Teaching Hospital, Nnewi, Nigeria

Publication date: 2011-08-01

  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more