Skip to main content

Free Content Murine cerebral malaria: histopathology and ICAM 1 immunohistochemistry of the inner ear

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Abstract:

Summary

Objective  To evaluate the pathophysiologic changes in the inner ear during the course of severe cerebral malaria in an established animal model, C57 BL/6J mice.

Methods  This study aims to examine the hearing threshold, the histological changes and ICAM‐1 expression in the murine cochlea.

Results  Four of seven mice showed an expected hearing loss of 20 dB or more. The light microscopy of the inner ear did not show any morphologic alterations. The immunohistochemical analysis for ICAM‐1 showed intensive staining in the stria vascularis of sick animals and hardly any reaction in healthy controls.

Conclusion  The up‐regulation of ICAM‐1 in the stria vascularis – generating the endocochlear potential – suggests its involvement in plasmodial infection.

Language: English

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1365-3156.2011.02801.x

Affiliations: 1:  Department of Otorhinolaryngology, Innsbruck Medical University, Innsbruck, Austria 2:  Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

Publication date: 2011-08-01

  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more