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Free Content Murine cerebral malaria: histopathology and ICAM 1 immunohistochemistry of the inner ear

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Objective  To evaluate the pathophysiologic changes in the inner ear during the course of severe cerebral malaria in an established animal model, C57 BL/6J mice.

Methods  This study aims to examine the hearing threshold, the histological changes and ICAM‐1 expression in the murine cochlea.

Results  Four of seven mice showed an expected hearing loss of 20 dB or more. The light microscopy of the inner ear did not show any morphologic alterations. The immunohistochemical analysis for ICAM‐1 showed intensive staining in the stria vascularis of sick animals and hardly any reaction in healthy controls.

Conclusion  The up‐regulation of ICAM‐1 in the stria vascularis – generating the endocochlear potential – suggests its involvement in plasmodial infection.

Language: English

Document Type: Research Article


Affiliations: 1:  Department of Otorhinolaryngology, Innsbruck Medical University, Innsbruck, Austria 2:  Department of Neurology, Innsbruck Medical University, Innsbruck, Austria

Publication date: 2011-08-01

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