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Free Content Rotavirus and norovirus infections in children in Sana’a, Yemen

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Summary Objectives  To describe the epidemiology of rotavirus and norovirus infection among children with acute gastroenteritis in Sana’a, Yemen. Methods  A cross-sectional study from November 2007 to March 2009 of children aged 1 month to 5 years attending the emergency and outpatient departments of two hospitals in Sana’a with acute gastroenteritis. Rotavirus was detected by ELISA and genotyped by RT-PCR. Norovirus was detected by End Point RT-PCR and nucleotide sequencing. Results  A total of 290 children (48% in the emergency department and 52% in the outpatient department of the children respectively) were enrolled. Rotavirus infections were detected in 78 (27%) and norovirus infections in 30 (10%). Rotavirus genotypes included G1P[8] (55%), G9P[8] (21%) and G2P[4] (12%) with G12 comprising 3% of strain types. The main norovirus genotype was GII.4 (27%) with >10 other genotypes detected. Conclusions  Rotavirus and norovirus infections are common causes of gastroenteritis in Yemen. Rotavirus vaccines could play a significant role in the control of acute childhood diarrhoea in this setting.

Infections à rotavirus et norovirus chez les enfants à Sanaa, au Yémen Objectifs: 

Décrire l’épidémiologie de l’infection à rotavirus et norovirus chez les enfants atteints de gastroentérite aiguëà Sanaa, au Yémen. Méthodes: 

Une étude transversale de novembre 2007 à mars 2009 chez les enfants âgés de 1 mois à 5 ans fréquentant les unités d’urgence et les services ambulatoires de deux hôpitaux à Sanaa, pour une gastroentérite aiguë. Le rotavirus a été détecté par ELISA et génotypé par RT-PCR. Le norovirus a été détecté par End Point RT-PCR et séquençage des nucléotides. Résultats: 

290 enfants (48% dans les unités d’urgence et 52% dans les services ambulatoires) ont été inscrits. Les infections à rotavirus ont été détectées chez 78 (27%) et à norovirus chez 30 (10%) enfants. Les génotypes trouvés pour le rotavirus étaient G1P [8] (55%), G9P [8] (21%) et G2P [4] (12%) avec G12 comprenant 3% des types de souches. Le principal génotype du norovirus était GII.4 (27%) avec plus de 10 autres génotypes détectés. Conclusions: 

Les infections à rotavirus et norovirus sont des causes fréquentes de gastroentérite au Yémen. Des vaccins anti-rotavirus pourraient jouer un rôle important dans le contrôle de la diarrhée aiguë de l’enfant dans ce cadre.
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Keywords: Norovirus; Yemen; Yémen; norovirus; rotavirus

Document Type: Research Article

Affiliations: 1:  Department of Clinical Infection, Microbiology & Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, UK 2:  Medical Faculty, Department of Paediatrics, Sana’a University, Sana’a, Yemen 3:  Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK 4:  Department of Paediatrics, Al-Thawra General Hospital, Sana’a, Yemen 5:  Department of Paediatric, Al-Sabeen Hospital, Sana’a, Yemen 6:  Clinical Infectious Disease Epidemiology, Liverpool School of Tropical Medicine, University of Liverpool, Liverpool, UK

Publication date: 01 June 2011

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