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Free Content Standardised versus actual white cell counts in estimating thick film parasitaemia in African children under five

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Abstract:

Summary In patients with malaria, parasitaemia is usually estimated by assuming 8000 white cell counts (WCC) per microlitre of blood. In a sample of 3044 African children under 5 years of age with uncomplicated falciparum malaria, parasitaemia estimated using standardised WCC was compared to parasitaemia calculated based on each child’s own WCC. The two methods produced comparable results. However, WCC were >8000 in under-fives with an inverse relationship with age, resulting in the standard approximation method significantly underestimating parasitaemia in the youngest age group and overestimating parasitaemia in the oldest age groups.

French
Communication brève: Parasitémie estimée et réelle dans la malaria aigüe non compliquée à Plasmodium falciparum chez les enfants africains de moins de cinq ans

Chez les patients malariques, la parasitémie est généralement estimée à partir du seuil de 8.000 globules blancs par microlitre de sang. Dans un échantillon de 3.044 enfants africains de moins de cinq ans avec une malaria non compliquée àP. falciparum, la parasitémie estimée et réelle (calculée sur base du taux de globules blancs de chaque enfant), n’étaient en général pas significativement différentes. Cependant, il y avait une association inverse entre le taux de globules blancs et l’âge, résultant ainsi au fait que la méthode d’approximation standard sous-estime nettement la parasitémie dans le groupe d’âge le plus jeune et surestime la parasitémie dans les groupes les plus âgés.

Keywords: conteo leucocitario; malaria; parasitaemia; parasitemia; parasitémie; taux de globules blancs; white cell counts

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1365-3156.2011.02738.x

Affiliations: 1:  Malaria Research and Training Center, University of Bamako, Bamako, Mali 2:  National Malaria Control Programme, Kigali, Rwanda 3:  Department of Parasitology, Cheikh Anta Diop University, Dakar, Senegal 4:  Centre National de Recherche et de Formation sur le Paludisme, Ministère de la Santé, Ouagadougou, Burkina Faso 5:  Department of Medicine, University of California San Francisco, San Francisco, CA, USA 6:  Drugs for Neglected Diseases Initiative, Geneva, Switzerland

Publication date: 2011-05-01

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