Free Content Mycobacterium tuberculosis in a HIV-1-infected population from Southeastern Brazil in the HAART era

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Abstract:

Summary Objective  To evaluate retrospectively the microbiological profile of species isolated from HIV-infected patients attending the HIV/TB reference health care units in São José do Rio Preto, Brazil. Method  Retrospective evaluation of all HIV-1 positive patients whose IAL-SJRP laboratorial analysis was positive for sp. after diagnosis of HIV Infection, from January 2000 to December 2006. Results  Of 198 patients, acid-fast staining detected mycobacteria early in 41%. Culture revealed 52.5% to be infected with (MT). 42.4% had non-tuberculous mycobacteria (NTM) and 5.1% had MT/NTM positive cultures. Eleven per cent of MT strains were resistant to at least one of the antimycobacterial drugs and 3.1% were multidrug resistant. 39.4% of isolated mycobacteria were NTM species Conclusion  Our data may serve as a starting point for further comparisons with other Brazilian regions and other developing countries. The data may provide important clues to the future understanding, prevention and control of such co-infections around the world.

French
Objectif: 

Evaluer rétrospectivement le profil microbiologique des espèces de Mycobacterium isolées de patients infectés par le VIH fréquentant des unités de soins de santé de référence pour la tuberculose/VIH à São José do Rio Preto, au Brésil. Méthode: 

Evaluation rétrospective de tous les patients VIH-1 positifs dont l’analyse IAL-SJRP de laboratoire était positive pour Mycobacterium sp, de janvier 2000 à décembre 2006. Résultats: 

Sur 198 patients, la coloration acido-résistante a permis de détecter des mycobactéries chez 41% d’eux. La culture a révélé 52,5% infectés par Mycobacterium tuberculosis (MT). 42,4% avaient des mycobactéries non-tuberculeuses (NTM) et 5,1% avaient des cultures positives pour MT et NTM. 11% des souches MT étaient résistantes à au moins un des médicaments antituberculeux, 3,1%étaient multirésistantes. 39,4% des mycobactéries isolées étaient des espèces NTM. Conclusion: 

Nos données pourraient servir de point de départ pour des comparaisons avec d’autres régions du Brésil et d’autres pays en développement. Les données pourraient fournir d’importants indices à la compréhension, prévention et au contrôle de telles coinfections à travers le monde.

Keywords: AIDS; Brasil; Brazil; Brésil; HIV; Mycobacterium tuberculosis; SIDA; VIH; drug resistance; resistencia antimicrobiana; résistance aux médicaments

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2010.02681.x

Affiliations: 1:  Adolfo Lutz Institute –Regional Laboratory from São José do Rio Preto, São Paulo, SP, Brazil 2:  Adolfo Lutz Institute – Central Laboratory from São Paulo, São Paulo, SP, Brazil 3:  DST/AIDS Specialized Attendance Service – São José do Rio Preto, São Paulo, SP, Brazil 4:  Department of Dermatological, Parasitical and Infectious Diseases from Faculty of Medicine from São José do Rio Preto, Center for Microorganisms Investigation, São Paulo, SP, Brazil 5:  Infectious and Parasitical Diseases Service from Hospital de Base – Faculty of Medicine from São José do Rio Preto Foundation, São Paulo, SP, Brazil 6:  Microbiology and Parasitical Diseases from Fluminense Federal University, Biomedical Institute, Niterói, RJ, Brazil.

Publication date: January 1, 2011

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