Free Content Epidemiology of parasitic co-infections during pregnancy in Lambaréné, Gabon

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Abstract:

Summary Objectives  To evaluate the epidemiologic data of parasitic infections and co-infections in pregnant women in Lambaréné, Gabon. Methods  In Lambaréné, Gabon – a region of high endemicity for and helminths – we conducted a longitudinal survey of malaria and helminth infections during pregnancy. Results  Of 388 pregnant women included in the study, 98 (25%) experienced at least one episode of infection (incidence of 2.6 infections per year of pregnancy). One hundred and seventy pregnant women (49%) were infected with intestinal helminths, and 41 (12%) harboured . In total, 230 (65%) pregnant women carried at least one parasitic infection are 74 (22%) harboured at least two or more parasite species. and primiparity were independently associated with infection during pregnancy [odds ratio (95% confidence intervals) 2.4, (1.4–3.8); 2.1, (1.3–3.5), respectively]. Conclusion  This study shows a high burden of parasitic infections with substantial degree of parasitic co-infections in pregnant women in a Central African region. This may have implications for immunological studies and operational research involving pregnant women.

French
Objectifs: 

Evaluer les données épidémiologiques des infections parasitaires et des co-infections chez les femmes enceintes à Lambaréné au Gabon. Méthodes: 

A Lambaréné au Gabon, une région de forte endémicité pour la malaria àP. falciparum et pour les helminthes, nous avons mené une surveillance longitudinale sur la malaria et les helminthiases durant la grossesse. Résultats: 

sur 388 femmes enceintes incluses dans l’étude, 98 (25%) ont connu au moins un épisode d’infection àP. falciparum (incidence de 2,6 infections par année de grossesse). 170 femmes enceintes (49%) étaient infectées par des helminthes intestinaux et 41 (12%) étaient porteuses de Schistosama haematobium. Au total, 230 (65%) femmes enceintes portaient au moins une infection parasitaire, 74 (32%) hébergeaient au moins deux ou plusieurs espèces de parasites. A. lumbricoides et la primiparitéétaient indépendamment associés à l’infection par le Plasmodium durant la grossesse (odds ratio [intervalle de confiance 95%] 2,4 ; [1,4 – 3,8] et 2,1 ; [1,3 à 3,5], respectivement). Conclusion: 

Cette étude montre une forte charge de morbidité des infections parasitaires avec un degré important de co-infections parasitaires chez les femmes enceintes dans une région d’Afrique centrale. Cela peut avoir des implications pour les études immunologiques et la recherche opérationnelle sur les femmes enceintes.

Keywords: Embarazo; Gabon; Gabón; co-infección; co-infection; grossesse; helminthes; helminths; helmintos; malaria; pregnancy

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2010.02598.x

Affiliations:  Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands

Publication date: October 1, 2010

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