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Free Content Tuberculosis research update

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Summary Tuberculosis (TB) remains a major challenge to global public health in the 21st century. In 2007, there were an estimated 9.27 million new cases and 1.3 million deaths among HIV-negative patients with TB. The HIV-associated TB epidemic, drug-resistant disease, the need for better diagnostic assays and the limited efficacy of Bacille Calmette–Guerin vaccination are four important obstacles to further progress in global TB control. In this brief review, we provide a focused update on these four key areas of TB research.

La tuberculose (TB) reste un défi majeur mondial pour la santé publique au XXIe siècle. En 2007, il y avait 9,27 millions de nouveaux cas et 1,3 million de décès estimés parmi les cas de TB négatifs pour le VIH. L’épidémie de TB associée au VIH, la résistance de la maladie aux médicaments, la nécessité de meilleurs tests de diagnostic et l’efficacité limitée du Bacille Calmette Guérin (BCG) sont quatre obstacles importants à des progrès supplémentaires dans la lutte mondiale contre la TB. Dans cette revue nous fournissons une mise à jour focalisée sur ces quatre domaines clés de la recherche sur la TB.

Keywords: HIV; VIH; diagnosis; diagnostic; diagnóstico; drug resistance; resistencia a medicamentos; résistance aux médicaments; tuberculose; tuberculosis; vaccin; vaccine; vacuna

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2010.02568.x

Affiliations:  South African Tuberculosis Vaccine Initiative, University of Cape Town, Cape Town, South Africa

Publication date: August 1, 2010

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