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Free Content Frequency of Val1016Ile mutation in the voltage‐gated sodium channel gene of Aedes aegypti Brazilian populations

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Abstract:

One of the major insect pyrethroid resistance mechanisms affects its target site, the voltage‐gated sodium channel (Nav). In Aedes aegypti, the Val1016Ile substitution of the AaNa v gene is associated to resistance in several Latin American countries. Genotyping of susceptible and resistant mosquitoes from seven Brazilian localities detected the 1016Ile mutation in five populations with a higher frequency of this substitution in resistant specimens in all cases. Furthermore, analysis of nine additional field populations revealed that five also presented the 1016Ile mutation. Our data suggest a recent dissemination and involvement of this substitution with pyrethroid resistance in Brazil.

Keywords: Resistencia piretroides; gen del canal de sodio; gène du canal sodium; kdr mutation; mutación kdr; mutation kdr; pyrethroid resistance; résistance aux pyréthroïdes; sodium channel gene

Language: English

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2009.02378.x

Affiliations:  Laboratório de Biologia Molecular de Insetos, Instituto Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil

Publication date: November 1, 2009

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