Frequency of Val1016Ile mutation in the voltage‐gated sodium channel gene of Aedes aegypti Brazilian populations
Abstract:One of the major insect pyrethroid resistance mechanisms affects its target site, the voltage‐gated sodium channel (Nav). In Aedes aegypti, the Val1016Ile substitution of the AaNa v gene is associated to resistance in several Latin American countries. Genotyping of susceptible and resistant mosquitoes from seven Brazilian localities detected the 1016Ile mutation in five populations with a higher frequency of this substitution in resistant specimens in all cases. Furthermore, analysis of nine additional field populations revealed that five also presented the 1016Ile mutation. Our data suggest a recent dissemination and involvement of this substitution with pyrethroid resistance in Brazil.
Document Type: Research Article
Affiliations: Laboratório de Biologia Molecular de Insetos, Instituto Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil
Publication date: November 1, 2009