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Free Content Design of epidemiological studies measuring genital and plasma HIV‐1 outcomes: lessons from a randomised controlled trial

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Abstract:

Objective  HIV‐1 genital viral loads have not been extensively used as markers of HIV transmissibility. We set out to determine whether the variability of genital HIV‐1 RNA over time necessitates design adjustments in studies measuring genital shedding to account for this variability.

Keywords: HIV‐1; VIH‐1; délestage génital; genital; genital shedding; medidas repetidas; mesures répétées; repeated measures; sample size; taille de l’échantillon; tamaño muestral

Language: English

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1365-3156.2009.02219.x

Affiliations: 1:  London School of Hygiene & Tropical Medicine, London, UK 2:  Transmission, Pathogenèse et Prévention de l’infection par le VIH, Université Montpellier 1, and Laboratoire de Bactériologie-Virologie, CHU Montpellier, France 3:  Centre Muraz, Bobo-Dioulasso, Burkina Faso

Publication date: 2009-03-01

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