Free Content ST2859 serogroup A meningococcal meningitis outbreak in Nouna Health District, Burkina Faso: a prospective study

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Abstract:

Summary We analysed cerebrospinal fluid samples from suspected meningitis cases in Nouna Health District, Burkina Faso, during the meningitis seasons of 2004–2006. Serogroup A ST2859 meningococci belonging to the ST5 clonal complex of subgroup III meningococci were the predominant causative agent. ST2859 bacteria were associated with focal outbreaks in the north of the district. While >10% of the population of an outbreak village carried ST2859, the population in the south of the district was predominantly colonised by serogroup Y ST4375 meningococci, which were associated with only sporadic cases of meningitis. Colonisation with the less virulent Y meningococci may interfere with the spread of the ST2859 to the south of the district, but there are concerns that this serogroup A clone may cause a third wave of subgroup III meningococcal disease in the African Meningitis Belt.

French
Étude prospective d’une épidémie de méningite méningococcale ST2859 du sérogroupe A, dans le district sanitaire de Nouna au Burkina-Faso

Nous avons analysé des échantillons de liquide céphalo-rachidien de cas suspects de méningite dans le district sanitaire de Nouna, au Burkina Faso, au cours des saisons de méningite de 2004 à 2006. Les méningocoques ST2859 du sérogroupe A appartenant au complexe clonal ST5 du sous-groupe III des méningocoques, étaient l’agent causal prédominant. Les bactéries ST2859 étaient associées à des foyers d’épidémie dans le nord du district. Alors que 10% de la population d’un village épidémique portaient le type ST2859, la population dans le sud du district était essentiellement colonisée par le sérogroupe de méningocoques Y ST4375, qui étaient seulement associés à des cas sporadiques de méningite. La colonisation par les méningocoques Y, moins virulents pourrait interférer avec la propagation des types ST2859 dans le sud du district, mais il y a des inquiétudes que ce clone du sérogroupe A puisse causer une troisième vague de maladies méningococcales du sous-groupe III dans la ceinture africaine de la méningite.

Keywords: Meningitis meningocócica; Neisseria meningitidis; Neisseria meningitidis serogroup A; Neisseria meningitidis serogrupo A; meningococcal meningitis; méningite à méningocoques; sérogroupe A

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2008.02056.x

Affiliations: 1:  Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso 2:  Molecular Immunology, Swiss Tropical Institute, Basel, Switzerland 3:  Section of Clinical Tropical Medicine, University Hospital Heidelberg, Heidelberg, Germany

Publication date: June 1, 2008

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