Free Content Human and porcine neurocysticercosis: differences in the distribution and developmental stages of cysticerci

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Abstract:

Summary Objective  To describe and compare the clinical impacts of neurocysticercosis (NC) caused by in humans and pigs. Methods  Comparative study of the brains of 16 asymptomatic pigs and 35 human NC cases (15 asymptomatic and 20 symptomatic). Results  In humans, cysticerci were more frequently located in the ventricles and subarachnoid space at the base of the brain (11.8% 1.6%;  = 0.001 and 25.9% 0%;  < 0.0001, respectively) while in pigs, cysticerci were more frequently found in the parenchyma (44.4% 7.6%;  < 0.0001). In human brains, 75.9% of the cysticerci were calcified, while in pigs all cysticerci were in the vesicular stage. Conclusion  The duration of infection and the host–parasite relationship (such as immune reactivity and brain haemodynamics) differ between humans and pigs. This may account for the different distribution and stage of the cysticerci among humans and pigs.

French
Objectif 

Décrire et comparer l’impact clinique de la neurocysticercose (NC) causés par Taenia solium chez les humains et les porcs. Méthodes 

Etude comparative des cerveaux de 16 porcs asymptomatiques et 35 cas humains (15 asymptomatiques et 20 symptomatiques) de NC. Résultats 

Chez l’homme, les cysticerques étaient plus souvent localisés dans les ventricules et l’espace sous-arachnoïdien, à la base du cerveau (11,8% vs 1,6%; P = 0,001 et 25,9% vs 0%; P < 0,0001, respectivement), alors que chez les porcs, les cysticerques étaient plus fréquemment trouvés dans le parenchyme (44,4% vs 7,6%, P < 0,0001). Dans les cerveaux humains, 75,9% des cysticerques étaient calcifiés, alors que chez les porcs tous les cysticerques étaient au stade vésiculaire. Conclusion 

La durée de l’infection et la relation hôte-parasite (telle que la réactivité immunitaire et l’hémodynamique du cerveau) diffèrent entre les humains et les porcs. Ceci peut expliquer la différence de la distribution et des stades des cysticerques chez l’humain et chez le porc.

Keywords: Neurocisticercosis; Neurocysticercose; Taenia solium; cisticercos; cisticercosis humana; cisticercosis porcina; cysticerci; cysticercose du porc; cysticercose humaine; cysticerques; human cysticercosis; neurocysticercosis; pig cysticercosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-3156.2008.02059.x

Affiliations: 1:  Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico DF, Mexico 2:  Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico DF, Mexico 3:  Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico DF, Mexico 4:  Instituto Nacional de Neurología y Neurocirugía, Mexico DF, Mexico

Publication date: May 1, 2008

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